Search results for "Calcium wave"

Chronic brain damage in HIV-infected individuals under antiretroviral therapy is associated with viral reservoirs, sulfatide release, and compromised…

2023

HIV infection has become a chronic and manageable disease due to the effective use of antiretroviral therapies (ART); however, several chronic aging-related comorbidities, including cognitive impairment, remain a major public health issue. However, these mechanisms are unknown. Here, we identified that glial and myeloid viral reservoirs are associated with local myelin damage and the release of several myelin components, including the lipid sulfatide. Soluble sulfatide compromised gap junctional communication and calcium wave coordination, essential for proper cognition. We propose that soluble sulfatide could be a potential biomarker and contributor to white matter compromise observed in H…

Author response: Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium waves

2017

Modeling of neuron-astrocyte interaction : application to signal and image processing

2022

The introduction of the tripartite synapse and the discovery of calcium wave propagation motivated our research to explore the potential of astrocytes as active components in brain circuits. For decades, astrocytes have been considered passive cells whose primary function is metabolic and structural support to neurons; however, recent physiological measurements suggest that astrocytes modulate neural communication, strengthen synaptic efficacy, enhance synchronization, and promote homeostasis. Inspired by these biological functions, this research aimed to implement astrocytes in artificial spiking networks for deep learning applications. First, we modeled the biological interaction between …